Resting Energy Expenditure in Adults With Williams Syndrome: Comparative Accuracy of Predictive Equations

These findings indicate that (i) the amount of FFM explains most of the mREE reduction observed when comparing females and males with WS, and when comparing WS and matched controls, and (ii) few predictive equations provide clinically useful REE estimates in adults with WS. More accurate predictions tended to originate from equations developed in cohorts with a high prevalence of overweight and obesity, or with older adults. These findings highlight the need for cautious application of pREE equation values in the clinical care of adults with WS and underscore the importance of continued investigation into energy requirements and their determinants.