Deletion of FGFR1 in hypothalamic neurons alters energy homeostasis and negates the metabolic effects of α-Klotho
Our results establish FGFR1 in hypothalamic neurons as an essential component of the pathway through which α-Klotho regulates systemic energy balance. These findings identify hypothalamic FGFR1 as a critical molecular target for developing anti-obesity therapies.
Authors
- Wyatt Bunner (ORCID: https://orcid.org/0000-0001-7590-5312)
- Taylor Landry (ORCID: https://orcid.org/0000-0002-5267-6585)
- Susan O’Çonnell (ORCID: https://orcid.org/0000-0002-5887-2771)
- Daniel Shookster (ORCID: https://orcid.org/0000-0003-3938-9626)
- Huang Hu (ORCID: https://orcid.org/0000-0003-1296-1645)
- Patel Darshan
Institutions
- East Carolina University (US)
Publication Details
- Journal
- Endocrinology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1210/endocr/bqaf182
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00