The efficacy of targeted therapies in metastatic squamous cell carcinoma of the lung: a Turkish Oncology Group multicentre study
This multicentre real-world study evaluated the efficacy of targeted therapies in Turkish patients with metastatic squamous cell lung carcinoma harbouring driver mutations. Sixty-four patients with alterations such as EGFR, ALK, and ROS1 who received targeted agents were retrospectively analysed. EGFR mutations were most common (67.2%). Among EGFR-TKI-treated patients, median progression-free survival (PFS) and overall survival (OS) were 12.4 and 14.3 months, respectively. Alectinib yielded a median PFS of 18.6 months and OS of 29.8 months in ALK-positive patients, while crizotinib produced a median PFS and OS of 7 months in ROS1-positive patients. The overall response rate was 50% and the disease control rate 84.4%. Although targeted therapies prolonged PFS compared with chemotherapy, this improvement did not translate into a significant OS advantage, likely influenced by retrospective design and treatment crossover. Findings represent real-world outcomes in a molecularly defined subgroup.
Authors
- Muhammet Bekir Hacıoğlu (ORCID: https://orcid.org/0000-0001-8490-3239)
- Gamze Gököz Doğu (ORCID: https://orcid.org/0000-0001-8142-0362)
- Bilgeşah Kılıçtaş (ORCID: https://orcid.org/0000-0002-2485-7901)
- Murat Arcagök (ORCID: https://orcid.org/0000-0001-7726-7975)
- Abdülkadir Koçanoğlu (ORCID: https://orcid.org/0000-0002-5579-2135)
- Atila Yıldırım
- Orhun Akdoğan (ORCID: https://orcid.org/0000-0003-0212-1191)
- Adem Deligönül (ORCID: https://orcid.org/0000-0002-3669-6391)
- Oğuzcan Kınıkoğlu (ORCID: https://orcid.org/0000-0001-5983-3291)
- Berna Çakmak Öksüzoğlu (ORCID: https://orcid.org/0000-0002-2756-8646)
- Atike Pınar Erdoğan (ORCID: https://orcid.org/0000-0003-4859-7574)
- Mevlüde İnanç (ORCID: https://orcid.org/0000-0002-3737-3420)
- Goncagül Akdağ (ORCID: https://orcid.org/0000-0002-6221-0623)
- Teoman Şakalar (ORCID: https://orcid.org/0000-0003-2749-9414)
- Tuğba Akın Telli (ORCID: https://orcid.org/0000-0001-6535-6030)
- Dilek Çağlayan (ORCID: https://orcid.org/0000-0003-4629-6815)
- Mehmet Artaç (ORCID: https://orcid.org/0000-0003-2335-3354)
- Murat Araz (ORCID: https://orcid.org/0000-0002-4632-9501)
- Mükremın Uysal (ORCID: https://orcid.org/0000-0002-8524-0665)
- Ahmet Fatih Oruç (ORCID: https://orcid.org/0009-0003-0923-5148)
- Ali Alkan (ORCID: https://orcid.org/0000-0002-8253-5046)
- Zuhat Urakçı (ORCID: https://orcid.org/0000-0003-3878-988X)
- Mahmut Büyükşimşek (ORCID: https://orcid.org/0000-0001-6356-9059)
- Deniz Işık (ORCID: https://orcid.org/0000-0003-4398-5148)
- Melek Karakurt Eryılmaz (ORCID: https://orcid.org/0000-0003-2597-5931)
- Elif Şahin (ORCID: https://orcid.org/0000-0002-1976-3951)
- Buket Erkan Özmarasalı (ORCID: https://orcid.org/0000-0003-2843-2748)
- Galip Can Uyar (ORCID: https://orcid.org/0000-0002-0698-777X)
- Ahmet Kürşad Dişli (ORCID: https://orcid.org/0000-0001-8014-4140)
- Gamze Serin Özel (ORCID: https://orcid.org/0009-0002-3631-6771)
- Tayyip İlker Aydın (ORCID: https://orcid.org/0000-0003-0064-954X)
- Nilüfer Avcı (ORCID: https://orcid.org/0000-0003-1094-5772)
- Ece Şahin Hafızoğlu (ORCID: https://orcid.org/0009-0007-7753-1482)
- Gamze Emin (ORCID: https://orcid.org/0000-0002-1549-7326)
- Yurdagül Danacı (ORCID: https://orcid.org/0009-0000-2414-8665)
Institutions
- Dicle University (TR)
- Trakya University (TR)
- Lahey Hospital and Medical Center (US)
- Karadeniz Technical University (TR)
- Manisa Celal Bayar University (TR)
- Bursa Technical University (TR)
- Inonu University (TR)
- Turkish Armed Forces (TR)
- State Hospital (GB)
- Ankara Atatürk Eğitim ve Araştırma Hastanesi (TR)
- Antalya Bilim University (TR)
- Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi (TR)
- Necmettin Erbakan University (TR)
- Memorial Sisli Hospital (TR)
- Gazi Hastanesi (TR)
- Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi (TR)
- Kahramanmaraş Sütçü İmam University (TR)
- Pamukkale University (TR)
- Kocaeli Üniversitesi (TR)
- Muğla University (TR)
- Erciyes University (TR)
- Gazi University (TR)
Publication Details
- Journal
- Journal of Chemotherapy
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1080/1120009x.2025.2601938
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00