A synergistic nanoformulation of propolis and chlorhexidine against <i>Acanthamoeba</i> : encapsulation efficiency, release kinetics, and safety evaluation
These results highlight that propolis-CHX-loaded chitosan nanoparticles (CS-NPs) show promise as a targeted, biocompatible therapy against drug-resistant <i>Acanthamoeba</i> cysts.
Authors
- Sonia M. Rodrigues Oliveira (ORCID: https://orcid.org/0000-0002-0707-5203)
- Veeranoot Nissapatorn (ORCID: https://orcid.org/0000-0001-8652-7556)
- N. Marimuthu (ORCID: https://orcid.org/0000-0002-7427-3111)
- Chooi Ling Lim (ORCID: https://orcid.org/0000-0002-2926-892X)
- Ryan V. Labana (ORCID: https://orcid.org/0000-0002-7158-343X)
- Tadesse Hailu Jember (ORCID: https://orcid.org/0000-0003-0116-1888)
- Patcharaporn Boonroumkaew (ORCID: https://orcid.org/0000-0001-5873-2392)
- Thiranut Jaroonwitchawan
- Maria de Lourdes Pereira (ORCID: https://orcid.org/0000-0001-6703-7869)
- Siriphorn Chimplee (ORCID: https://orcid.org/0000-0002-2949-0467)
- Guo-Jie Brandon-Mong (ORCID: https://orcid.org/0000-0002-1673-8021)
- Wenn-Chyau Lee (ORCID: https://orcid.org/0000-0002-7324-5792)
- Samudi Chandramathi
- Tajudeen O. Jimoh (ORCID: https://orcid.org/0000-0002-3629-5272)
- Muhammad Nawaz (ORCID: https://orcid.org/0000-0001-9016-9229)
- Rhun Yian Koh (ORCID: https://orcid.org/0000-0003-4190-8288)
- Shanmuga Sundar Saravanabhavan (ORCID: https://orcid.org/0000-0003-0598-4187)
- Watcharapong Mitsuwan (ORCID: https://orcid.org/0000-0002-5257-4626)
- Christophe Wiart (ORCID: https://orcid.org/0000-0003-2824-7286)
- Victor Varun Raju Sowri
Institutions
- Agency for Science, Technology and Research (SG)
- Universiti of Malaysia Sabah (MY)
- Vinayaka Missions University (IN)
- Khon Kaen University (TH)
- Polytechnic University of the Philippines (PH)
- University of Malaya (MY)
- Biodiversity Research Center, Academia Sinica (TW)
- Bahir Dar University (ET)
- University of Aveiro (PT)
- IMU University (MY)
- Imam Abdulrahman Bin Faisal University (SA)
- University of Santo Tomas (PH)
- Walailak University (TH)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- PeerJ
- Published
- 2025-12-19
- DOI
- https://doi.org/10.7717/peerj.20493
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.00