A synergistic nanoformulation of propolis and chlorhexidine against <i>Acanthamoeba</i> : encapsulation efficiency, release kinetics, and safety evaluation

These results highlight that propolis-CHX-loaded chitosan nanoparticles (CS-NPs) show promise as a targeted, biocompatible therapy against drug-resistant <i>Acanthamoeba</i> cysts.

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Publication Details

Journal
PeerJ
Published
2025-12-19
DOI
https://doi.org/10.7717/peerj.20493
Primary Topic
Legionella and Acanthamoeba research
Type
article
Field-Weighted Citation Impact
0.00
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article

A synergistic nanoformulation of propolis and chlorhexidine against Acanthamoeba : encapsulation efficiency, release kinetics, and safety evaluation

Sonia M. Rodrigues Oliveira, Veeranoot Nissapatorn, N. Marimuthu, Chooi Ling Lim et al.
PeerJ
Legionella and Acanthamoeba research
article

A synergistic nanoformulation of propolis and chlorhexidine against Acanthamoeba : encapsulation efficiency, release kinetics, and safety evaluation

Sonia M. Rodrigues Oliveira, Veeranoot Nissapatorn, N. Marimuthu, Chooi Ling Lim, Ryan V. Labana, Tadesse Hailu Jember, Patcharaporn Boonroumkaew, Thiranut Jaroonwitchawan, Maria de Lourdes Pereira, Siriphorn Chimplee, Guo-Jie Brandon-Mong, Wenn-Chyau Lee, Samudi Chandramathi, Tajudeen O. Jimoh, Muhammad Nawaz, Rhun Yian Koh, Shanmuga Sundar Saravanabhavan, Watcharapong Mitsuwan, Christophe Wiart, Victor Varun Raju Sowri
article en

Abstract

These results highlight that propolis-CHX-loaded chitosan nanoparticles (CS-NPs) show promise as a targeted, biocompatible therapy against drug-resistant <i>Acanthamoeba</i> cysts.

PeerJVol. 13
Agency for Science, Technology and Research (SG), Universiti of Malaysia Sabah (MY), Vinayaka Missions University (IN), Khon Kaen University (TH), Polytechnic University of the Philippines (PH), University of Malaya (MY), Biodiversity Research Center, Academia Sinica (TW), Bahir Dar University (ET), University of Aveiro (PT), IMU University (MY), Imam Abdulrahman Bin Faisal University (SA), University of Santo Tomas (PH), Walailak University (TH), Icahn School of Medicine at Mount Sinai (US)
Openalex Percentile: Top 65%
Legionella and Acanthamoeba research
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