Histological analysis of age-related degeneration in human female and male knee cartilage and meniscus
Tissue degeneration assessed by OARSI grades and modified Pauli scores increase with age in persons without clinically-evident knee arthritis. However, about half of the elderly donors show only mild degeneration. There was a small association between degeneration and male sex, for both tissues. Cartilage and meniscus degeneration within knees without clinically-evident arthritis were weakly associated.
Authors
- Iida Hellberg (ORCID: https://orcid.org/0000-0003-2824-9310)
- Neserin Ali (ORCID: https://orcid.org/0000-0002-8483-471X)
- Anders Aspberg (ORCID: https://orcid.org/0000-0002-6588-6944)
- Amanda Sjögren (ORCID: https://orcid.org/0000-0003-4531-2860)
- Ville‐Pauli Karjalainen (ORCID: https://orcid.org/0000-0001-8376-2454)
- Aleksandra Turkiewicz (ORCID: https://orcid.org/0000-0003-1460-2275)
- Velocity Hughes (ORCID: https://orcid.org/0000-0002-3869-7726)
- Patrik Önnerfjord (ORCID: https://orcid.org/0000-0002-2345-2937)
- Martin Englund (ORCID: https://orcid.org/0000-0003-3320-2437)
- Sara Bodahl
Institutions
- Lund University (SE)
- University of Oulu (FI)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100734
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00