Identification of alkaline phosphatase as a putative biomarker of anti-NGF treatment-associated arthropathies: Machine learning-assisted analyses of clinical trial data
Change in ALP (baseline to week 16) was associated with AA events after treatment with fasinumab. Other measured peripheral biomarkers were not linked with AA events.
Authors
- Dateng Li (ORCID: https://orcid.org/0000-0002-4287-5337)
- Matthew F. Wipperman (ORCID: https://orcid.org/0000-0003-1436-3366)
- Simon Eng (ORCID: https://orcid.org/0009-0001-4964-5729)
- Sara Hamon (ORCID: https://orcid.org/0000-0002-2413-2302)
- Yamini Patel (ORCID: https://orcid.org/0000-0003-0095-2231)
- Jennifer D. Hamilton (ORCID: https://orcid.org/0000-0003-1236-5245)
- Erica Chio (ORCID: https://orcid.org/0009-0002-9001-6892)
- Kristie T. Ota
- Bret J. Musser (ORCID: https://orcid.org/0000-0003-2949-211X)
- Henry Wei (ORCID: https://orcid.org/0000-0002-5887-8348)
- Haitao Gao
- Gregory P. Geba (ORCID: https://orcid.org/0000-0001-8936-748X)
- Debra A.G. McIntyre (ORCID: https://orcid.org/0000-0002-8079-4124)
- Poulabi Banerjee (ORCID: https://orcid.org/0000-0001-5304-9543)
- Peter J. Ehmann (ORCID: https://orcid.org/0000-0001-8037-5731)
- Stephen J. DiMartino (ORCID: https://orcid.org/0009-0001-0592-7644)
- Stefanie J. Hectors (ORCID: https://orcid.org/0000-0001-9457-6606)
- Yoshiteru Ushirogawa
- Garen Manvelian (ORCID: https://orcid.org/0000-0002-5491-1032)
- Chenguang Wang (ORCID: https://orcid.org/0000-0003-1926-5722)
- Kei Ogawa
- Tina Ho
Institutions
- Regeneron (United States) (US)
- Mitsubishi Tanabe Pharma Corporation
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100735
- Primary Topic
- Alkaline Phosphatase Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00