Standard- versus high-dose tigecycline in pneumonia due to carbapenem-resistant Acinetobacter baumannii: A propensity score–matched retrospective study
High-dose tigecycline improved microbiological eradication but did not enhance survival or clinical outcomes and was associated with greater toxicity. These findings support cautious use of high-dose tigecycline in CRAB pneumonia pending randomized controlled trials.
Authors
- Sultan Arslan‐Tontul (ORCID: https://orcid.org/0000-0003-1557-7948)
- Özge Özgen Top (ORCID: https://orcid.org/0000-0003-1468-4960)
- Murat Dizbay
- Fatma Zehra Özcan
- Elif Ayça Şahin (ORCID: https://orcid.org/0000-0002-2215-2756)
- Zeynep Tekin-Taş (ORCID: https://orcid.org/0000-0001-7232-8863)
- Elif Erkan (ORCID: https://orcid.org/0009-0001-8514-4753)
- Pınar Aysert Yıldız
Institutions
- Ministry of Health (TR)
- Bingöl University (TR)
- Gazi University (TR)
Publication Details
- Journal
- Infectious Diseases Now
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.idnow.2025.105242
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00