Immunosuppressive Tumor Microenvironment in Colorectal Cancer Lung Metastases: Implications for Recurrence After Metastasectomy
Immunosuppressive features including enrichment of SPP1+ TAMs and depletion of effector T and NK cells contribute to recurrence after CRC lung metastasectomy. Therapeutic strategies targeting both TAMs and T cells may enhance clinical outcomes in this patient population.
Authors
- Yeong Jeong Jeon (ORCID: https://orcid.org/0000-0001-6745-6131)
- Jeeyun Lee (ORCID: https://orcid.org/0000-0002-4911-6165)
- Minsuk Kwon (ORCID: https://orcid.org/0000-0003-1833-6576)
- Sung Hee Lim (ORCID: https://orcid.org/0000-0001-9369-597X)
- Yoonah Park (ORCID: https://orcid.org/0000-0003-3930-3319)
- Tae Hee Hong (ORCID: https://orcid.org/0000-0003-2708-8893)
- Minae An (ORCID: https://orcid.org/0009-0007-9575-7952)
- Yong Soo Choi (ORCID: https://orcid.org/0000-0001-8492-7644)
- Min‐Kyue Shin (ORCID: https://orcid.org/0000-0002-0938-7315)
- Yong Beom Cho (ORCID: https://orcid.org/0000-0002-9944-4706)
- Jung Kyong Shin
- Seung Tae Kim
Institutions
- Yonsei University (KR)
- Samsung Medical Center (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-12-17
- DOI
- https://doi.org/10.4143/crt.2025.691
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- Ministry of Science and ICT, South Korea
- Samsung