Continuous flow synthesis of epinephrine through modularized multienzyme cascades
A four-enzyme cascade was developed for the enantioselective synthesis of epinephrine in a modular continuous-flow system. This process yielded pharmaceutical-grade epinephrine with a space–time yield of 2.17 g L −1 h −1 and 97.1% enantiomeric excess.
Authors
- Zhenkun Zhang (ORCID: https://orcid.org/0000-0002-3480-2381)
- Zejiao Liu
- Xi–Wei Lin (ORCID: https://orcid.org/0000-0003-0098-0638)
- Wenhao Meng
- Yifei Zhang (ORCID: https://orcid.org/0000-0001-6077-8525)
Institutions
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Green Chemistry
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1039/d5gc05637c
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 0.00