Lipoteichoic Acid Stimulation of Macrophages Causes Mitochondrial Dysfunction
This study suggests that enhancing mitochondrial function with agents such as Mdivi-1 could serve as a novel therapeutic strategy for refractory apical periodontitis by modulating immune responses and reducing chronic inflammation, potentially improving treatment outcomes in clinically challenging cases.
Authors
- Guixin Li (ORCID: https://orcid.org/0000-0001-9689-8705)
- Huan Liu (ORCID: https://orcid.org/0009-0003-9927-9370)
- Xin Liu (ORCID: https://orcid.org/0000-0002-6634-4012)
- Weiwei Zhang (ORCID: https://orcid.org/0000-0001-9365-5791)
- Siyao Liu (ORCID: https://orcid.org/0009-0004-4144-4449)
- Shuang Pan
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.identj.2025.109290
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47