Algorithm-based assessment of T-cell dysfunction and exclusion to forecast ICB sensitivity in pediatric brain ependymoma
Pediatric ependymomas are not uniformly immune-silent. ZFTA-RELA and recurrent tumors exhibit a "primed but suppressed" immune phenotype, where the immune machinery is present but functionally restrained, suggesting greater susceptibility to ICB, whereas PF-A tumors remain immune-excluded and may require microenvironmental modulation to achieve immunotherapy benefit.
Authors
- Alessandro Olivi (ORCID: https://orcid.org/0000-0002-4489-7564)
- Alessio Albanese
- Francesco Doglietto (ORCID: https://orcid.org/0000-0002-7438-0734)
- Luca Massimi (ORCID: https://orcid.org/0000-0003-3088-0822)
- Giampiero Tamburrini
- Matteo Palermo
- Carmelo Lucio Sturiale
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1007/s11060-025-05384-4
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università Cattolica del Sacro Cuore