Dissecting antibody-mediated NK cell effects reveals a cytotoxic CX3CR1⁺KLRC2⁻CD16 <sup>hi</sup> subset linked to HBV outcomes
Our data contribute to the understanding of antibody-mediated responses of NK cells in chronic HBV infection, and highlight a previously unappreciated functional CX3CR1+KLRC2-CD16hiNK subset as a potential therapeutic target.
Authors
- Jianru Sun (ORCID: https://orcid.org/0000-0003-4457-9387)
- Shihong Zhong (ORCID: https://orcid.org/0000-0003-1075-6322)
- Weiying He (ORCID: https://orcid.org/0000-0003-0241-7056)
- Zihan Jin
- Linnan Song (ORCID: https://orcid.org/0000-0002-3921-2911)
- Xiangyong Li (ORCID: https://orcid.org/0000-0003-1131-5123)
- Libo Tang (ORCID: https://orcid.org/0000-0002-7905-5893)
- Lingtao Zhang (ORCID: https://orcid.org/0009-0007-7426-741X)
- Zhaofeng Zeng (ORCID: https://orcid.org/0000-0002-0492-0555)
- Yujing Zhang (ORCID: https://orcid.org/0000-0002-8265-2488)
- Yuhao Wang (ORCID: https://orcid.org/0000-0003-2943-434X)
- Liping Wang (ORCID: https://orcid.org/0000-0002-3458-4513)
- Yurong Gu (ORCID: https://orcid.org/0000-0002-9178-8205)
- Yongyin Li
- Weixin He
- Yi Xuan (ORCID: https://orcid.org/0000-0003-4622-2955)
- Xiaoqin Lan
Institutions
- Sun Yat-sen University (CN)
- Nanfang Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3350/cmh.2025.0842
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Nanfang Hospital
- Basic and Applied Basic Research Foundation of Guangdong Province