Neonatal-onset multisystem inflammatory disease caused by a de novo NLRP3 gene mutation: a case report and literature review
This case highlights the importance of early recognition of NOMID in neonates with antibiotic-unresponsive systemic inflammation. Early genetic confirmation and targeted IL-1 blockade with canakinumab are crucial to preventing devastating complications.
Authors
- Wenhao Yuan
- Lingxia Zhao
- Lingkong Zeng
Institutions
- Wuhan Children's Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fped.2025.1702819
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00