Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages
A previously unappreciated action of disulfiram to inhibit PANoptosis both <i>in vitro</i> and <i>in vivo</i> was discovered, thus repurposing this anti-alcoholism drug for the treatment of PANoptosis-related inflammatory diseases.
Authors
- X. H. Niu (ORCID: https://orcid.org/0009-0003-2877-6863)
- Xian‐Hui He (ORCID: https://orcid.org/0000-0001-7433-7392)
- Qingbing Zha
- Dong‐Yun Ouyang (ORCID: https://orcid.org/0000-0002-4743-942X)
- Zijian Shi (ORCID: https://orcid.org/0000-0001-9698-3563)
- Onyee Chan (ORCID: https://orcid.org/0000-0003-2872-1961)
- Nan Sun (ORCID: https://orcid.org/0000-0001-6812-9917)
- Yaping Li (ORCID: https://orcid.org/0000-0002-0574-6966)
- Ge Zhang (ORCID: https://orcid.org/0000-0002-4904-3330)
- Bo Hu (ORCID: https://orcid.org/0000-0003-3591-1480)
Institutions
- Xinjiang Medical University (CN)
- Jinan University (CN)
- University of Jinan (CN)
- Sixth Affiliated Hospital of Xinjiang Medical University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1726408
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81