PSMD14 drives lung adenocarcinoma progression through HMMR stabilization and dual activation of TGF-β/Smad and PI3K/AKT/mTOR signaling

Our findings demonstrate that PSMD14 acts as a key driver of LUAD progression by stabilizing HMMR and consequently activates both the TGF-β/Smad and PI3K/AKT/mTOR signaling pathways. Consequently, the PSMD14-HMMR axis emerges as a promising therapeutic target. Inhibition of PSMD14 exhibited significant anti-tumor efficacy, underscoring its potential for clinical translation in LUAD treatment.