Establishing standardized transthoracic echocardiography reference ranges for mouse models: insights into the impact of anesthesia, sex, and age
Validation of the reference ranges across multiple mouse strains showed that these values provide a reliable baseline for experiments involving cardiac function in mice. The data underscore the importance of using anesthesia-specific reference values when interpreting TTE results, ensuring robust comparisons in genetic and pharmacological studies. These reference ranges serve as quality assurance tools for future cardiac studies in mice, offering insights into typical TTE parameter values, supporting the detection of experimental perturbations, and contributing to more effective translation of findings from mice to humans.
Authors
- Martin Hrabě de Angelis (ORCID: https://orcid.org/0000-0002-7898-2353)
- Helmut Fuchs (ORCID: https://orcid.org/0000-0002-5143-2677)
- Manuela A. Oestereicher
- Elida Schneltzer (ORCID: https://orcid.org/0000-0003-4796-1661)
- Syed Waleem Pasha (ORCID: https://orcid.org/0009-0000-1334-2059)
- Helen E. Parkinson (ORCID: https://orcid.org/0000-0003-3035-4195)
- Christopher Ward (ORCID: https://orcid.org/0000-0002-3445-6327)
- Jason D. Heaney (ORCID: https://orcid.org/0000-0001-8475-8828)
- David Pajuelo Reguera (ORCID: https://orcid.org/0000-0002-7715-9402)
- Lydia Teboul (ORCID: https://orcid.org/0000-0002-2789-8637)
- Mayra Monroy
- Sara Wells (ORCID: https://orcid.org/0000-0002-0572-0600)
- Zuzana Nichtová (ORCID: https://orcid.org/0000-0001-7358-3268)
- Radislav Sedláček (ORCID: https://orcid.org/0000-0002-3352-392X)
- Federico López (ORCID: https://orcid.org/0000-0002-7138-3542)
- Clare Norris
- Eva Zábrodská (ORCID: https://orcid.org/0009-0007-3614-7943)
- Valérie Gailus‐Durner (ORCID: https://orcid.org/0000-0002-6076-0111)
- Ghina Bou About (ORCID: https://orcid.org/0009-0003-1234-7466)
- Hamid Méziane (ORCID: https://orcid.org/0000-0002-4704-7055)
- Susan Marschall (ORCID: https://orcid.org/0000-0001-5191-7060)
- Yann Hérault (ORCID: https://orcid.org/0000-0001-7049-6900)
- Mohammed Selloum (ORCID: https://orcid.org/0000-0003-4057-3519)
- Nadine Spielmann (ORCID: https://orcid.org/0000-0003-2699-0068)
- Dale Pimm
- Xiang Gao (ORCID: https://orcid.org/0000-0003-2617-6509)
- Jan Procházka (ORCID: https://orcid.org/0000-0002-2370-8795)
- Michelle Stewart
- M N Kan
- Robert Wilson (ORCID: https://orcid.org/0000-0002-9407-5526)
Institutions
- Baylor College of Medicine (US)
- Center for Environmental Health (US)
- Mary Lyon Centre at MRC Harwell (GB)
- Phénotypage et ingénierie précliniques des systèmes d’organismes modèles (FR)
- Model Animal Research Center (CN)
- Bioinformatics Institute (RU)
- Biomedical Research Institute (US)
- Czech Academy of Sciences, Institute of Molecular Genetics (CZ)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- German Center for Diabetes Research (DE)
- Technical University of Munich (DE)
- Université de Strasbourg (FR)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fcvm.2025.1695034
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39