Ginsenoside Rh2 Suppresses the Fanconi Anemia Pathway by Inhibiting NF-κB-Mediated FANCL Transcription in Bladder Cancer
Ginsenoside Rh2 suppresses NF-κB signaling to transcriptionally downregulate FANCL, thereby impairing FA pathway-mediated DNA repair and enhancing cisplatin cytotoxicity in bladder cancer. These findings highlight Rh2 as a potential combinatorial agent to overcome platinum resistance.
Authors
- Guanglin Lv (ORCID: https://orcid.org/0009-0008-2635-5412)
- Z.Y. Wang (ORCID: https://orcid.org/0009-0003-0097-2301)
- Chen Li (ORCID: https://orcid.org/0009-0007-8601-9296)
- Zhuang Xiong (ORCID: https://orcid.org/0009-0003-8849-5756)
Institutions
- Wuxi No.2 People's Hospital (CN)
Publication Details
- Journal
- Dose-Response
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1177/15593258251411761
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00