Plasma cell-free DNA genome-wide methylation profiling enables detection and activity assessment in systemic lupus erythematosus
Multi-omics analyses indicate that frequently aberrant methylation sites are correlated with immune-related pathways, disease onset and progression. The analysis of cfDNA methylation profiles can serve as a diagnostic tool for distinguishing disease states and assessing disease severity in SLE.
Authors
- Yijing Liu (ORCID: https://orcid.org/0000-0002-7503-3910)
- Fang Wang (ORCID: https://orcid.org/0009-0009-4639-4985)
- Yiqun Zhang (ORCID: https://orcid.org/0000-0002-0822-6384)
- Zhen Chen (ORCID: https://orcid.org/0000-0002-0569-1686)
- Zhihua Pei (ORCID: https://orcid.org/0000-0001-7973-9489)
Institutions
- Tongji University (CN)
- Fujian Medical University (CN)
- Huazhong Agricultural University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
- 303 Hospital of People's Liberation Army (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1721954
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00