Tumor-associated high endothelial venules are associated with enhanced lymphocyte infiltration and favorable prognosis in resected hepatocellular carcinoma
TA-HEVs in HCC were associated with significantly better prognosis and may contribute to immune activation within the tumor microenvironment.
Authors
- Daisaku Yamada (ORCID: https://orcid.org/0000-0002-6702-3800)
- Tadafumi Asaoka
- Hirofumi Akita (ORCID: https://orcid.org/0000-0002-3115-9466)
- Hisashi Wada (ORCID: https://orcid.org/0000-0002-5444-6193)
- Yuichiro� Doki (ORCID: https://orcid.org/0000-0001-7346-0209)
- Azumi Ueyama (ORCID: https://orcid.org/0009-0007-1352-761X)
- Shu Aoyama (ORCID: https://orcid.org/0000-0002-6576-5958)
- Takehiro Noda (ORCID: https://orcid.org/0000-0002-6768-5783)
- Eiichi Morii (ORCID: https://orcid.org/0000-0001-8490-3650)
- Takuro Saito (ORCID: https://orcid.org/0000-0002-1733-5064)
- Hidenori Takahashi (ORCID: https://orcid.org/0000-0003-4801-3540)
- Junzo Shimizu (ORCID: https://orcid.org/0000-0002-6613-5341)
- Shogo Kobayashi (ORCID: https://orcid.org/0000-0003-2305-942X)
- Yosuke Mukai (ORCID: https://orcid.org/0000-0002-4951-8033)
- Hidetoshi Eguchi
- Shinichiro Hasegawa
- Kazuki Sasaki (ORCID: https://orcid.org/0009-0006-9126-0351)
- Yoshito Tomimaru
- Kansuke Kido
Institutions
- Osaka Gakuin University (JP)
- Toyonaka Municipal Hospital (JP)
- Shionogi (Japan) (JP)
- Osaka Hospital (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1007/s00262-025-04265-z
- Citations
- 1
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81