Efficacy and safety of hepatic arterial infusion chemotherapy plus lenvatinib and PD-1/PD-L1 inhibitors versus systemic chemotherapy plus lenvatinib and PD-1/PD-L1 inhibitors in advanced unresectable cholangiocarcinoma: a retrospective cohort study
HAIC-based triple therapy provided superior tumor control, prolonged survival, and preserved hepatic function with acceptable safety in unresectable iCCA.
Authors
- Boheng Zhang (ORCID: https://orcid.org/0000-0001-6040-2210)
- Meixia Wang (ORCID: https://orcid.org/0000-0002-3139-1847)
- Yanfang Wu (ORCID: https://orcid.org/0000-0002-4225-3992)
- Guobin Chen (ORCID: https://orcid.org/0000-0002-3587-7094)
- Zhenzhen Zhang (ORCID: https://orcid.org/0000-0002-5151-3602)
- Xiaochun Chen (ORCID: https://orcid.org/0000-0001-5146-9288)
- Xinkun Guo
Institutions
- Xiamen University (CN)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1007/s00262-025-04255-1
- Citations
- 1
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Bethune Charitable Foundation
- Fudan University
- Natural Science Foundation of Fujian Province