Treadmill exercise alleviates Alzheimer’s disease pathologies in APP/PS1 mice through modulation of microglial glucose metabolic reprogramming
Treadmill exercise promotes microglial glucose metabolic remodeling, which attenuates neuroinflammation and Aβ pathology, and restores spatial learning and memory deficits in APP/PS1 mice.
Authors
- Feng Sun (ORCID: https://orcid.org/0000-0003-4334-6805)
- Fei Liang (ORCID: https://orcid.org/0000-0002-9351-9375)
- Chu Guo (ORCID: https://orcid.org/0000-0002-3411-3076)
- Hui Zhong (ORCID: https://orcid.org/0000-0002-1292-3983)
Institutions
- Gannan Normal University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fnagi.2025.1734837
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00