Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae: risk factors and resistance mechanism of ceftazidime/avibactam in China
China faces a rapid dissemination of ST11 CR-hvKP clones carrying diversified CZA resistance mechanisms. The convergence of hypervirulence and resistance in ST11 lineages-accelerated by invasive procedures and international transmission-demands enhanced genomic surveillance. CZA resistance arises through multiple pathways, necessitating combination therapies and stewardship programs limiting prolonged CZA use. Our findings underscore an urgent need for rapid diagnostics targeting emergent resistance determinants and infection control measures to contain high-risk clones.
Authors
- Junliang Chang
- Bu Wang (ORCID: https://orcid.org/0009-0005-8933-8036)
- Xinya Peng (ORCID: https://orcid.org/0000-0001-9095-5780)
- Jianhua Tang (ORCID: https://orcid.org/0000-0003-0018-4084)
- Jianhua Hao (ORCID: https://orcid.org/0000-0002-7634-7567)
- Licai Deng (ORCID: https://orcid.org/0000-0001-9073-9914)
- Chunmei Lei
- Jianhua Liu (ORCID: https://orcid.org/0009-0006-4821-3189)
- Na Wang (ORCID: https://orcid.org/0000-0003-2600-2162)
- Huiying Li (ORCID: https://orcid.org/0000-0001-5633-5270)
- Jia Na (ORCID: https://orcid.org/0000-0002-8112-8924)
- Wei Zhang
Institutions
- Hebei North University (CN)
- Tianjin Nankai Hospital (CN)
- Tianjin Tianhe Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fcimb.2025.1698033
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00