Emodin and physcion alleviate cholestatic liver injury by targeting FXR: hepatoprotective components identified in processed Polygonum multiflorum Thunb. using a comprehensive two-dimensional biochromatography system
This study established a novel, efficient, rapid, and accurate comprehensive 2D FXR biochromatography system, which is suitable for screening targeted components in TCM, and can be extended to research on other TCMs.
Authors
- Yanqiu Gu (ORCID: https://orcid.org/0000-0002-0280-6062)
- Jianbo Yang (ORCID: https://orcid.org/0000-0002-1368-5294)
- Shaozhan Wang
- Yongfang Yuan (ORCID: https://orcid.org/0000-0003-1123-2379)
- Ru Yao (ORCID: https://orcid.org/0000-0003-2863-6919)
- Ying Wang
- Shengnan Li (ORCID: https://orcid.org/0000-0003-1111-5981)
- Zhihui Li (ORCID: https://orcid.org/0000-0001-5356-932X)
- Panpan Chen (ORCID: https://orcid.org/0000-0003-0056-612X)
- Rong Wang (ORCID: https://orcid.org/0000-0001-6129-4055)
- Fangbin Liu
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- National Institutes for Food and Drug Control (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fphar.2025.1706401
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Institutes for Food and Drug Control
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Wu Jieping Medical Foundation