LAT1 expression in head and neck cancer: a prognostic biomarker with potential relevance for BNCT
High LAT1 expression has a negative prognostic role and is associated with transcriptomic clusters with unfavorable and radioresistant biologic features. These results justify the use of BNCT in radioresistant HNSCCs and may guide patient selection for future clinical studies with BNCT.
Authors
- Imperia Nuzzolese (ORCID: https://orcid.org/0000-0001-6293-5301)
- Lisa Licitra
- Marta Lucchetta (ORCID: https://orcid.org/0000-0002-2641-4792)
- Stefano Cavalieri (ORCID: https://orcid.org/0000-0003-1294-6859)
- Deborah Lenoci (ORCID: https://orcid.org/0000-0002-5958-8035)
- Marica Ficorilli (ORCID: https://orcid.org/0009-0005-0991-0769)
- Ester Orlandi (ORCID: https://orcid.org/0000-0003-1588-3558)
- Loris De Cecco
Institutions
- University of Milan (IT)
- University of Pavia (IT)
- National Center for Oncological Hadrontherapy (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fonc.2025.1678011
- Citations
- 1
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro