Quantifying TERT promoter mutations in tumor-derived DNA shed into the oral cavity as a potential biomarker for oral squamous cell carcinoma
TERTp C228T and C250T are mutually exclusive and occur at a high frequency in oral rinses and tumor tissues of OSCC patients, showing high concordance between paired samples. These findings support the potential of TERTp mutations as non-invasive biomarkers for OSCC detection. Moreover, their higher prevalence in males suggests possible sex-related differences in OSCC mutation patterns.
Authors
- Sara Amiranda (ORCID: https://orcid.org/0000-0003-3995-3864)
- Rita De Berardinis (ORCID: https://orcid.org/0000-0003-4959-587X)
- Luisa Dassi (ORCID: https://orcid.org/0000-0002-2350-1997)
- Andrea Cerasuolo (ORCID: https://orcid.org/0000-0002-6410-7515)
- Fausto Maffini (ORCID: https://orcid.org/0000-0002-4554-8956)
- Giovanni Blandino (ORCID: https://orcid.org/0000-0002-6970-2241)
- Tarik Gheit (ORCID: https://orcid.org/0000-0001-7088-337X)
- Mohssen Ansarin (ORCID: https://orcid.org/0000-0002-8384-5388)
- Marta Tagliabue (ORCID: https://orcid.org/0000-0002-7879-4846)
- Massimo Tommasino (ORCID: https://orcid.org/0000-0002-0890-8596)
- Maria Lina Tornesello (ORCID: https://orcid.org/0000-0002-3523-3264)
- Noemy Starita (ORCID: https://orcid.org/0000-0002-5169-7640)
- Anna Lucia Tornesello (ORCID: https://orcid.org/0000-0003-0972-5668)
- T. Cimmino
- Susanna Chiocca (ORCID: https://orcid.org/0000-0002-9721-0850)
- Giuseppe De Palma (ORCID: https://orcid.org/0000-0002-6108-096X)
- Stefania Vecchio (ORCID: https://orcid.org/0000-0001-5903-5310)
- Angelo Paradiso
Institutions
- Istituto Tumori Bari (IT)
- National Cancer Institute (MY)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Ospedale Policlinico San Martino (IT)
- Centre international de recherche sur le cancer (FR)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fonc.2025.1720783
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00