Dietary vitamin B9 intake linked to drug-resistant epilepsy risk in western Chinese adults: exploring underlying metabolomic mechanisms

This study identifies lower dietary vitamin B9 intake as an independent risk factor for DRE in a Chinese adult cohort, with each 100 μg increase conferring a 22% reduction in risk. The metabolomic findings provide potential mechanistic insights, linking folate intake to dysregulated stress hormone, inflammatory, and one-carbon metabolism pathways in DRE. These results highlight the potential of nutritional assessment and intervention in the management of drug-resistant epilepsy.