Epigenetic silencing of SPHK1-IRF7 axis drives inflammaging in age-related meniscus degeneration via sphingolipid-immune dysregulation
SPHK1 and IRF7 drive inflammaging via sphingolipid-immune crosstalk and epigenetic silencing, offering diagnostic and therapeutic potential.
Authors
- Lingcheng Wang
- Shun-Jie Yang (ORCID: https://orcid.org/0000-0003-4649-7289)
- Xiaohe Tian (ORCID: https://orcid.org/0000-0002-2294-3945)
- Li Liu (ORCID: https://orcid.org/0000-0003-2493-3086)
- Hui Wang (ORCID: https://orcid.org/0000-0003-2568-7200)
- Gang Chen (ORCID: https://orcid.org/0000-0001-7322-5292)
- Peng Xu (ORCID: https://orcid.org/0000-0002-2825-7276)
Institutions
- Xiamen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- West China Hospital of Sichuan University (CN)
- Second People’s Hospital of Yibin (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1186/s13018-025-06518-0
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00