Polydatin alleviates mitochondrial damage and apoptosis of lung epithelial cells by inhibiting toll‐like receptor 4‐dependent macrophage activation in asthma
Polydatin is a promising therapeutic candidate for asthma, possibly by targeting macrophage-epithelium cross-talk via the TLR4/P2X7R axis. Future formulations as capsules or sprays may effectively alleviate airway inflammation and remodeling.
Authors
- Liangchang Li
- Jianing Yang (ORCID: https://orcid.org/0000-0002-2706-0818)
- Ruobai Liu
- Li Li (ORCID: https://orcid.org/0000-0002-7720-6731)
- Chongyang Wang (ORCID: https://orcid.org/0000-0001-8943-7214)
- Jingzhi Jiang (ORCID: https://orcid.org/0000-0003-0858-1703)
- Yilan Song (ORCID: https://orcid.org/0000-0002-6351-3810)
- Chang Xu (ORCID: https://orcid.org/0000-0003-2262-5194)
- Guangxing Li (ORCID: https://orcid.org/0000-0002-6705-2222)
Institutions
- Yanbian University (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1002/ame2.70100
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00