TP53 mutations as drivers of chordoma progression and hallmarks of aggressive chordoma
TP53 mutations are acquired during chordoma progression and are associated with an aggressive phenotype; TP53 sequencing could serve as a prognostic and potentially predictive biomarker in aggressive chordomas.
Authors
- Bartosz Wojtaś (ORCID: https://orcid.org/0000-0002-9967-910X)
- Paulina Kober (ORCID: https://orcid.org/0000-0002-7735-8137)
- Szymon Baluszek
- Thibault Passeri (ORCID: https://orcid.org/0000-0003-4759-0389)
- Michał Wągrodzki (ORCID: https://orcid.org/0000-0001-5211-0736)
- Bożena Kamińska (ORCID: https://orcid.org/0000-0002-2642-4616)
- Mateusz Bujko (ORCID: https://orcid.org/0000-0001-5826-8446)
- Tomasz Mandat (ORCID: https://orcid.org/0000-0003-3480-0412)
- Jacek Kunicki (ORCID: https://orcid.org/0000-0002-2304-7974)
- Paulina Szadkowska (ORCID: https://orcid.org/0000-0001-8125-4843)
Institutions
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Université Paris Cité (FR)
- Hôpital Lariboisière (FR)
- National Institute of Oncology (HU)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Institut Curie (FR)
Publication Details
- Journal
- Acta Neuropathologica Communications
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1186/s40478-025-02180-z
- Primary Topic
- Bone Tumor Diagnosis and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00