Hemoglobin-to-red blood cell distribution width ratio and risk of fragility fracture: A 16-year prospective cohort study
This large-scale study is the first to demonstrate a significant inverse association between HRR and fragility fracture risk. HRR remained an independent protective factor after multivariable adjustment, and, as a simple, low-cost inflammatory biomarker, it demonstrates potential for early identification and risk stratification of high-risk individuals.
Authors
- Shuli Wei (ORCID: https://orcid.org/0000-0001-9554-1990)
- Xiaoli Hou
- Wenchao Yao
- Bin Zhang (ORCID: https://orcid.org/0000-0002-2127-9560)
- Nan Zhang (ORCID: https://orcid.org/0000-0002-6978-7695)
- Liu Zhang (ORCID: https://orcid.org/0000-0001-5239-3561)
- Lei Xing (ORCID: https://orcid.org/0000-0003-2536-5359)
- Yixuan Ma (ORCID: https://orcid.org/0009-0008-4842-3965)
- Haibing Li (ORCID: https://orcid.org/0000-0002-6374-4694)
- Lu Guo (ORCID: https://orcid.org/0000-0003-4369-2513)
- Faming Tian (ORCID: https://orcid.org/0000-0001-7083-3380)
- Jingyuan Gao
Institutions
- North China University of Science and Technology (CN)
- Kailuan General Hospital (CN)
- North China University of Science and Technology Affiliated Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Journal of the Formosan Medical Association
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jfma.2025.12.025
- Citations
- 2
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.09