Metformin and incident osteoarthritis: Causal insights from a co-twin control study
Starting metformin treatment may be associated with a decreased risk of incident diagnosis of OA in specialist care over an 11-year follow-up period. The 10-year cumulative incidence was ∼3 percentage points lower among metformin initiators than non-initiators.
Authors
- Karin Magnusson (ORCID: https://orcid.org/0000-0003-4851-5794)
- Aleksandra Turkiewicz (ORCID: https://orcid.org/0000-0003-1460-2275)
- Andrea Dell’Isola (ORCID: https://orcid.org/0000-0002-0319-458X)
- Ali Kiadaliri (ORCID: https://orcid.org/0000-0002-4254-9099)
- Martin Englund (ORCID: https://orcid.org/0000-0003-3320-2437)
Institutions
- Lund University (SE)
Publication Details
- Journal
- Osteoarthritis and Cartilage
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.joca.2025.12.014
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Karolinska Institutet
- Vetenskapsrådet
- Greta och Johan Kocks stiftelser
- Reumatikerförbundet