From association to mechanism: Why single-omics biomarker discovery in JIA demands a systems integration paradigm
• Critiques single-omics design in JIA biomarker discovery. • Proposes a multi-omics systems integration paradigm. • Links microbiome-metabolome to mechanistic insight. • Suggests a translational framework for future studies.
Authors
- Jiehua Han (ORCID: https://orcid.org/0009-0004-4495-388X)
- Qi Xu (ORCID: https://orcid.org/0000-0001-8537-9301)
Institutions
- Ningbo No. 2 Hospital (CN)
- Ningbo University Affiliated Hospital (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.biopha.2025.118934
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 0.00