Dolutegravir/lamivudine versus bictegravir/emtricitabine/tenofovir alafenamide fumarate: Real-world assessment of effectiveness and weight Gain in naïve people living with HIV of Asian OrigiN (DRAGON)
In this large real-world Asian cohort, BIC/FTC/TAF and DTG/3TC demonstrated comparable virological efficacy. However, TAF-containing regimen-particularly among individuals with lower CD4 counts and BMI-were associated with greater weight gain and attenuated increases in HDL cholesterol, highlighting the need for careful metabolic monitoring.
Authors
- Meiyin Zou
- Linghua Li (ORCID: https://orcid.org/0000-0001-5711-8681)
- Shu-Yuan Lee
- Hsin-Hao Lai
- Shu‐Hsing Cheng (ORCID: https://orcid.org/0000-0002-6256-0527)
- Chien‐Yu Cheng (ORCID: https://orcid.org/0000-0002-1886-0370)
- Tung-Che Hung (ORCID: https://orcid.org/0000-0001-7871-4706)
- Cheng‐Pin Chen (ORCID: https://orcid.org/0000-0002-0629-9790)
- Miao‐Hui Huang (ORCID: https://orcid.org/0000-0001-8961-1104)
- Wen-Hsin Hsih
- Yiwen Wu (ORCID: https://orcid.org/0000-0001-8310-6385)
- Tsung‐Chia Chen (ORCID: https://orcid.org/0000-0002-3461-5535)
- Yi‐Chun Lin (ORCID: https://orcid.org/0000-0002-8287-1429)
- Chia‐Jui Yang (ORCID: https://orcid.org/0000-0002-5925-2064)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-6193-2675)
- Ping Ma (ORCID: https://orcid.org/0000-0002-5728-3596)
- Qingxia Zhao
- Mao-Song Tsai
- Mao-Wang Ho
Institutions
- Ministry of Health and Welfare (KR)
- National Yang Ming Chiao Tung University (TW)
- China Medical University (TW)
- Nantong University (CN)
- Min Sheng General Hospital (TW)
- Tzu Chi Foundation (TW)
- Taipei Municipal YangMing Hospital (TW)
- Far Eastern Memorial Hospital (TW)
- Second People's Hospital of NanTong (CN)
- Chia-Yi Christian Hospital (TW)
- Tianjin People's Hospital (CN)
- Tao Yuan General Hospital (TW)
- Taipei City Hospital (TW)
- Ministry of Health and Welfare (TW)
- Hualien Tzu Chi Medical Center (TW)
- China Medical University Hospital (TW)
- Taichung Hospital (TW)
- Wuxi Third People's Hospital (CN)
- Buddhist Tzu Chi Medical Foundation (US)
- The Sixth People's Hospital of Zhengzhou (CN)
- Guangzhou Eighth People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.ijid.2025.108321
- Citations
- 1
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.25