Chronic stress drives ovarian cancer progression via myeloid-derived suppressor cells infiltration and Notch signaling pathway activation
These data indicate that chronic stress leads to MDSCs infiltration and suppressive activity, which contributes to an immunosuppressive TME and OC progression.
Authors
- Melanie Ortiz-León
- Paulo C. Rodrı́guez (ORCID: https://orcid.org/0000-0001-7480-6566)
- Yadiel A. Rivera-López
- Jaileene Pérez‐Morales (ORCID: https://orcid.org/0000-0003-3569-2396)
- Alexandra N. Aquino-Acevedo
- Shelley S. Tworoger (ORCID: https://orcid.org/0000-0002-6986-7046)
- Guillermo N. Armaiz-Peña (ORCID: https://orcid.org/0000-0002-9081-5339)
- Mary K. Townsend (ORCID: https://orcid.org/0000-0003-2452-4477)
- Grace Duffey (ORCID: https://orcid.org/0000-0002-5286-3671)
- Orlando I. Torres-Rodríguez (ORCID: https://orcid.org/0000-0001-6714-148X)
- Lauren Cole Peres (ORCID: https://orcid.org/0000-0002-6620-8600)
- Yesenia Castillo-Ocampo (ORCID: https://orcid.org/0000-0002-0913-2734)
- Luis M. Rivera-Pérez (ORCID: https://orcid.org/0000-0002-5898-1759)
- Luinet L. Meléndez-Rodríguez
- Jaydiel A. Casiano-Martínez
- Alanis P. Torres-Rosado
- Sofía M. Hernández-Carrasquillo
- Raian Imad-Hamad
Institutions
- Ponce Health Sciences University (PR)
- Oregon Health & Science University (US)
- University of Puerto Rico System (PR)
- Puerto Rico Department of Health (PR)
- University of Puerto Rico at Ponce (PR)
- Moffitt Cancer Center (US)
- University of Puerto Rico-Mayaguez (PR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1593299
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80