Prognostic factors of patients with intravascular large B cell lymphoma: a multicenter study in China
Intravascular large B-cell lymphoma (IVLBCL) is a rare and highly aggressive lymphoma, but current knowledge is still inadequate. We retrospectively analyzed 50 IVLBCL patients from five Chinese tertiary hospitals in China between 2017 and 2024. Hemophagocytic variant (HV) patients showed worse performance status, universal B symptoms, more bone marrow infiltration, higher mortality, pancytopenia, elevated inflammatory markers (CRP, LDH, ferritin), hypoglobulinemia and hypogammaglobulinemia. Among 46 treated patients, CR/CRu rate was 71% (27/38). The 2-year OS was 65.5%, significantly worse in HV vs. classical variant (CV) (43.3% vs. 76.4%, <i>P</i> = 0.007). Multivariate analysis identified CNS involvement (HR = 10.86, <i>P</i> < 0.001), HV subtype (HR = 1.91, <i>P</i> = 0.018), and nodal organs involvement (HR = 5.26, <i>P</i> = 0.052) as poor prognostic factors. IVLBCL exhibits marked heterogeneity, with HV and CNS involvement conferring dismal outcomes. This study provides key diagnostic/therapeutic insights for IVLBCL in China, warranting prospective trials to validate prognostic models and optimize therapies.
Authors
- Yi Zhao (ORCID: https://orcid.org/0000-0001-6046-8420)
- Jinghang Zhang
- Jingsong He
- Yu Kang (ORCID: https://orcid.org/0000-0002-8706-3252)
- Zhengwu Sun (ORCID: https://orcid.org/0000-0002-4314-0447)
- Wenjun Wu (ORCID: https://orcid.org/0000-0003-0044-1917)
- Lixia Zhu (ORCID: https://orcid.org/0000-0002-8762-278X)
- Yi Zhong (ORCID: https://orcid.org/0000-0002-0626-7510)
- Yun Liang (ORCID: https://orcid.org/0009-0003-7066-1816)
- Yan Guo (ORCID: https://orcid.org/0000-0002-8754-1090)
- Xiujin Ye (ORCID: https://orcid.org/0000-0002-4553-2751)
- Fengping Zhou
- Zhen Cai
- Xian Li (ORCID: https://orcid.org/0000-0002-9107-5096)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-9231-0844)
- Xiufeng Wang (ORCID: https://orcid.org/0000-0002-9557-049X)
- Guoqing Lv (ORCID: https://orcid.org/0000-0002-9591-1098)
- Yan Huang
- Xiaojing Lin (ORCID: https://orcid.org/0000-0001-6052-4234)
- Hanjin Yang
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fonc.2025.1689028
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00