SAA restricts T cell mediated anti-tumor immunity by limiting antigen presentation in lung cancer
our results identify SAA as an important immunosuppressive mediator in the tumor microenvironment, implying that the SAA neutralizing antibody may be a potential target for the improvement of lung cancer immunotherapy.
Authors
- Cong Xu (ORCID: https://orcid.org/0000-0002-7467-2083)
- Run Shi (ORCID: https://orcid.org/0000-0003-4667-4812)
- Chunbin Wang (ORCID: https://orcid.org/0000-0002-3299-130X)
- Feng Jiang (ORCID: https://orcid.org/0000-0001-5416-4316)
- Mei Huang (ORCID: https://orcid.org/0000-0003-0915-018X)
- Guoren Zhou (ORCID: https://orcid.org/0000-0001-5344-8480)
- Shaodi Wen (ORCID: https://orcid.org/0000-0001-7951-0123)
- Xin Wang (ORCID: https://orcid.org/0000-0002-5122-2418)
- Yihan Zhang (ORCID: https://orcid.org/0009-0009-1515-3257)
- Bo Shen (ORCID: https://orcid.org/0000-0002-7826-0684)
- Xiaoyue Du
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Yancheng Third People's Hospital (CN)
- Jiangsu Cancer Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1735479
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00