Effect of Linaclotide on Colonic Motility Assessed With Intraluminal Colonic High‐Resolution Manometry in Healthy Subjects. An Acute, Open Label, Randomized, Crossover, Reader‐Blinded Study
In healthy controls, acute administration of linaclotide increases the total number of long-distance propagating sequences and the pre-prandial pancolonic pressurizations.
Authors
- Ingrid Demedts (ORCID: https://orcid.org/0000-0003-0596-4944)
- Christian Lambiase (ORCID: https://orcid.org/0000-0002-9565-5039)
- Jan F. Tack (ORCID: https://orcid.org/0000-0002-3206-6704)
- Eveline Deloose (ORCID: https://orcid.org/0000-0001-8694-7745)
- Silvia Cocca (ORCID: https://orcid.org/0000-0002-0642-8054)
- Maura Corsetti (ORCID: https://orcid.org/0000-0003-2957-4684)
- Giuseppe Pagliaro
- Riccardo Morganti (ORCID: https://orcid.org/0000-0001-7783-0262)
Institutions
- University of Pisa (IT)
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Santa Maria Nuova Hospital (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- NIHR Nottingham Digestive Diseases Biomedical Research Unit (GB)
- Azienda Ospedaliera Universitaria Pisana (IT)
- Catholic University of America (US)
- KU Leuven (BE)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1111/nmo.70222
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering