A Cooperative Release of Mitochondrial <scp>DNA</scp> From Platelets and Neutrophils Drives an Interferon Signature in Systemic Sclerosis
SSc plasma is characterized by highly abundant mtDNA, which drives feedback loops amplifying its own release from both neutrophils and platelets. Thus, mtDNA contributes to inflammation and tissue damage in SSc.
Authors
- Diego Kyburz (ORCID: https://orcid.org/0000-0003-4506-4190)
- Ulrich A. Walker (ORCID: https://orcid.org/0000-0002-9183-550X)
- Enrico Ferrero (ORCID: https://orcid.org/0000-0002-8362-100X)
- Anton Glück (ORCID: https://orcid.org/0000-0003-1937-3950)
- Tobias Junt (ORCID: https://orcid.org/0000-0003-0260-8346)
- Stavros Giaglis (ORCID: https://orcid.org/0000-0003-2216-9539)
- Cédric André
- André N. Tiaden (ORCID: https://orcid.org/0000-0003-4506-4190)
- Stuart Hawtin (ORCID: https://orcid.org/0000-0002-5754-061X)
- Simone Häner‐Massimi
Institutions
- Novartis (Switzerland) (CH)
- University Hospital of Basel (CH)
- Department of Biomedicine Basel (CH)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1002/art.70027
- Citations
- 2
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Science Foundation
- Universitätsspital Basel
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Novartis Pharma