Role of the retinoid X receptor–peroxisome proliferator-activated receptor-γ axis in adolescent attention-deficit hyperactivity disorder
To the best of our knowledge, this study is the first to demonstrate reduced peripheral RXR-α levels in human adolescents with ADHD, independent of medication status and symptom severity, extending preclinical retinoid signaling evidence. Further investigation is required to elucidate the neuromechanisms linking ADHD to the RXR-PPAR-γ axis.
Authors
- Mu‐Hong Chen (ORCID: https://orcid.org/0000-0001-6516-1073)
- Shih‐Jen Tsai (ORCID: https://orcid.org/0000-0002-9987-022X)
- Li-Chi Chen (ORCID: https://orcid.org/0000-0002-3167-3959)
- Ya‐Mei Bai (ORCID: https://orcid.org/0000-0003-3779-9074)
- Ju‐Wei Hsu
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
- Cheng Hsin General Hospital (TW)
Publication Details
- Journal
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1007/s00406-025-02178-7
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Taiwan University