PINK1 dysfunction in hepatocellular carcinoma fosters immune evasion and disease progression by promoting neutrophil infiltration
Our study uncovered PINK1 as both a predictor of the ICB response and a key mediator of immune evasion by promoting neutrophil infiltration. These results highlight that the therapeutic targeting of neutrophils may represent a viable strategy to overcome ICB resistance in HCC.
Authors
- Na Zhuang (ORCID: https://orcid.org/0000-0002-3908-2360)
- Yuanze Zhou (ORCID: https://orcid.org/0000-0002-8542-6048)
- Zhiyun Gu (ORCID: https://orcid.org/0000-0002-3849-3053)
- Yuanli Ni (ORCID: https://orcid.org/0000-0003-3645-3979)
- Cheng Qian (ORCID: https://orcid.org/0000-0003-1500-9991)
- Tongwang Yang (ORCID: https://orcid.org/0009-0006-7089-9121)
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Southwest Hospital (CN)
- Chongqing Cancer Hospital (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/jitc-2025-013079
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80