Epigenomic study of the lower airway reveals COPD-associated methylation patterns and potential microbiota links

Bronchial epithelial DNA methylation modules enriched for lung function GWAS loci associate with COPD severity in SPIROMICS. Potential module relationships to bronchial bacterial composition require further validation.

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Publication Details

Journal
BMJ Open Respiratory Research
Published
2025-12-01
DOI
https://doi.org/10.1136/bmjresp-2025-003572
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
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article

Epigenomic study of the lower airway reveals COPD-associated methylation patterns and potential microbiota links

Nadia N. Hansel, Stephanie A. Christenson, Wendy C. Moore, Eric A. Hoffman et al.
BMJ Open Respiratory Research
Gut microbiota and health
article

Epigenomic study of the lower airway reveals COPD-associated methylation patterns and potential microbiota links

Nadia N. Hansel, Stephanie A. Christenson, Wendy C. Moore, Eric A. Hoffman, Igor Barjaktarević, MeiLan K. Han, Timothy D. Howard, Richard E. Kanner, Yvonne J. Huang, Annette T. Hastie, Benjamin M. Smith, Victor E. Ortega, Jeffrey L. Curtis, Robert J. Kaner, Joe Zein, Wanda K. O’Neal, Siddharth Madapoosi, Deborah A. Meyers, John R. Erb‐Downward, Sudan Cao, Prescott G. Woodruff, Russell Bowler, Alejandro P. Comellas, Christopher B. Cooper, Robert Paine, David Couper, Xianfeng Chen, Fernando J. Martínez, Victor Kim, Robert Graham Barr, Abhishek Shrivastav, Gregory A. Hawkins, Eugene R. Bleecker
article en

Abstract

Bronchial epithelial DNA methylation modules enriched for lung function GWAS loci associate with COPD severity in SPIROMICS. Potential module relationships to bronchial bacterial composition require further validation.

BMJ Open Respiratory ResearchVol. 12(1)
University of North Carolina at Chapel Hill (US), University of Iowa (US), Cleveland Clinic (US), Johns Hopkins University (US), University of California, Los Angeles (US), University of Massachusetts Chan Medical School (US), University of California, San Francisco (US), Cornell University (US), University of Utah (US), University of Michigan (US), Columbia University Irving Medical Center (US), Johns Hopkins Medicine (US), Mayo Clinic in Arizona (US), University of Utah Health Care (US), Wake Forest University (US), Columbia University (US), Temple University (US)
Openalex Percentile: Top 63%
Gut microbiota and health
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