Epigenomic study of the lower airway reveals COPD-associated methylation patterns and potential microbiota links
Bronchial epithelial DNA methylation modules enriched for lung function GWAS loci associate with COPD severity in SPIROMICS. Potential module relationships to bronchial bacterial composition require further validation.
Authors
- Nadia N. Hansel (ORCID: https://orcid.org/0000-0002-8740-9751)
- Stephanie A. Christenson (ORCID: https://orcid.org/0000-0003-1550-2815)
- Wendy C. Moore (ORCID: https://orcid.org/0000-0001-6869-3059)
- Eric A. Hoffman (ORCID: https://orcid.org/0000-0001-8456-9437)
- Igor Barjaktarević (ORCID: https://orcid.org/0000-0002-8096-0858)
- MeiLan K. Han (ORCID: https://orcid.org/0000-0002-9095-4419)
- Timothy D. Howard (ORCID: https://orcid.org/0000-0003-2518-4902)
- Richard E. Kanner (ORCID: https://orcid.org/0000-0001-6915-599X)
- Yvonne J. Huang (ORCID: https://orcid.org/0000-0002-7497-6597)
- Annette T. Hastie (ORCID: https://orcid.org/0000-0001-6607-7797)
- Benjamin M. Smith (ORCID: https://orcid.org/0000-0002-0619-5799)
- Victor E. Ortega (ORCID: https://orcid.org/0000-0002-3962-0528)
- Jeffrey L. Curtis (ORCID: https://orcid.org/0000-0001-5191-4847)
- Robert J. Kaner (ORCID: https://orcid.org/0000-0003-0527-576X)
- Joe Zein (ORCID: https://orcid.org/0000-0001-6850-7236)
- Wanda K. O’Neal (ORCID: https://orcid.org/0000-0003-2412-5943)
- Siddharth Madapoosi (ORCID: https://orcid.org/0000-0002-6858-0449)
- Deborah A. Meyers (ORCID: https://orcid.org/0000-0001-5399-8423)
- John R. Erb‐Downward (ORCID: https://orcid.org/0000-0002-4233-758X)
- Sudan Cao (ORCID: https://orcid.org/0009-0009-3414-9616)
- Prescott G. Woodruff (ORCID: https://orcid.org/0000-0003-3176-0603)
- Russell Bowler
- Alejandro P. Comellas (ORCID: https://orcid.org/0000-0003-1521-7520)
- Christopher B. Cooper (ORCID: https://orcid.org/0000-0002-6314-0903)
- Robert Paine (ORCID: https://orcid.org/0000-0002-4511-4437)
- David Couper (ORCID: https://orcid.org/0000-0002-4313-9235)
- Xianfeng Chen (ORCID: https://orcid.org/0000-0001-7091-1414)
- Fernando J. Martínez (ORCID: https://orcid.org/0000-0002-2412-3182)
- Victor Kim (ORCID: https://orcid.org/0000-0002-1385-1571)
- Robert Graham Barr
- Abhishek Shrivastav
- Gregory A. Hawkins
- Eugene R. Bleecker
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Iowa (US)
- Cleveland Clinic (US)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- University of Massachusetts Chan Medical School (US)
- University of California, San Francisco (US)
- Cornell University (US)
- University of Utah (US)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Mayo Clinic in Arizona (US)
- University of Utah Health Care (US)
- Wake Forest University (US)
- Columbia University (US)
- Temple University (US)
Publication Details
- Journal
- BMJ Open Respiratory Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/bmjresp-2025-003572
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00