Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Cardiovascular Disease Incidence in Adults With Prediabetes: Findings From the Diabetes Prevention Program
In adults with prediabetes, higher plasma concentrations of select PFAS, but not their mixture, were prospectively associated with increased CVD risk. These findings underscore PFAS as a potential environmental risk factor for CVD in high-risk populations. <b>REGISTRATION:</b> URL: https://clinicaltrials.gov/; Unique identifiers: NCT00004992 and NCT00038727.
Authors
- Diane R. Gold (ORCID: https://orcid.org/0000-0001-8789-418X)
- Marinella Temprosa (ORCID: https://orcid.org/0000-0002-9976-745X)
- Abby F. Fleisch (ORCID: https://orcid.org/0000-0002-2789-6412)
- Andrés Cárdenas (ORCID: https://orcid.org/0000-0003-2284-3298)
- Emily Oken (ORCID: https://orcid.org/0000-0003-2513-3339)
- Antonia M. Calafat (ORCID: https://orcid.org/0000-0002-9796-7482)
- Pi‐I D. Lin (ORCID: https://orcid.org/0000-0003-3564-4255)
- Julianne Cook Botelho (ORCID: https://orcid.org/0000-0002-6740-7169)
Institutions
- Brigham and Women's Hospital (US)
- Milken Institute (US)
- Maine Medical Center (US)
- Harvard University (US)
- George Washington University (US)
- National Center for Environmental Health (US)
- MaineHealth (US)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Center for Urban Population Health (US)
- Harvard Pilgrim Health Care (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1161/jaha.125.046298
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.00