Impaired Pituitary Axis Following Traumatic Skull Base Fracture and Associated Brain Injury

An increase in pituitary hormone on the day of injury may be attributed to physiological adaptation to acute illness. Post-TBI pituitary dysfunction is a clinically significant entity. Secondary hypoadrenalism, hypothyroidism, and central diabetes insipidus should be treated acutely, while deficiencies in growth and gonadotrophic hormones should initially be observed. A follow-up strategy with periodic evaluation is a necessary part of the optimal care for patients with TBI.