4-Phenylbutyric acid extends the gold time of uncontrolled hemorrhagic shock at high altitude by alleviating vital organ injury
PBA administration during hypotensive resuscitation protects vital organs (heart, liver, kidney), reduces pulmonary and cerebral edema incidence, and significantly extends the golden period for UHS at high altitudes.
Authors
- Yujun Zhu (ORCID: https://orcid.org/0000-0001-8389-174X)
- Liangming Liu (ORCID: https://orcid.org/0000-0001-6001-8729)
- Xinming Xiang
- Zisen Zhang (ORCID: https://orcid.org/0000-0003-0098-2668)
- Yuanqun Zhou
- Qing-Hui Li
- Li Wang (ORCID: https://orcid.org/0000-0001-5084-9596)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-9381-9706)
- Tao Li (ORCID: https://orcid.org/0000-0002-7988-3090)
- Yue Wu (ORCID: https://orcid.org/0000-0002-4102-4055)
- Xiaoyong Peng
- Haoyue Deng
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s40635-025-00833-w
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China