Early genetic events in the colorectal carcinogenic pathway of familial adenomatous polyposis and sporadic polyp: germline and somatic alterations in carcinogenesis
An identical cancer pathway may be associated with multistep carcinogenesis, accompanied by <i>APC</i> mutations in mutation hotspots. A combined analysis of germline and somatic alterations revealed 'three-hit' alterations in the <i>APC</i> gene among the FAP patients, suggesting that the heterogeneity of colorectal carcinogenesis contribute to these genetic changes.
Authors
- Yu Kobayashi (ORCID: https://orcid.org/0000-0002-6196-604X)
- Keitaro Takahashi (ORCID: https://orcid.org/0000-0003-4188-0246)
- Mishie Ann Tanino (ORCID: https://orcid.org/0000-0003-3370-0452)
- Yusuke Mizukami (ORCID: https://orcid.org/0000-0002-1068-7024)
- Nobuhiro Ueno
- Toshikatsu Okumura (ORCID: https://orcid.org/0000-0003-1810-007X)
- Nobue Tamamura
- Shin Kashima (ORCID: https://orcid.org/0000-0001-8309-4281)
- Hiroki Tanabe (ORCID: https://orcid.org/0000-0001-9029-5081)
- Kentaro Moriichi (ORCID: https://orcid.org/0000-0002-1298-3265)
- Katsuyoshi Ando (ORCID: https://orcid.org/0000-0003-3500-5488)
- Yusuke Ono (ORCID: https://orcid.org/0000-0001-8385-5386)
- Hidehiro Takei (ORCID: https://orcid.org/0000-0002-2095-670X)
- Mikihiro Fujiya
Institutions
- Asahikawa Medical University (JP)
- Sapporo Higashi Tokushukai Hospital (JP)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fgene.2025.1668133
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00