Supragingival Biomarker flora of Children With and Without Cariogenic Disease and Black Stains, Aged 3 to 6 Years

The diversity of the microbial community has little influence on the development of dental caries and black staining. However, specific bacteria exhibited different relative abundances across the HC, SECC, BSCF, and SECCBS groups; therefore, those bacteria may serve as candidate biomarkers. Co-occurrence network approaches and differential machine learning models can be used to predict a spectrum of dental caries in primary dentition, providing a convenient and preventive strategy.