Oncolytic HSV-1–Mediated JAG1 Blockade Induces Glioma Senescence-Associated Secretory Phenotype to Increase Macrophage Activation and Cetuximab-Mediated Senolysis
Leveraging JAG1 antagonism in the context of oncolytic virotherapy rewires macrophage polarization within the tumor microenvironment, which has wide implications for sensitizing tumors to antibodies, senolytic agents, and BiTE therapies.
Authors
- Tae Jin Lee (ORCID: https://orcid.org/0000-0002-5245-1140)
- Ashok Sharma (ORCID: https://orcid.org/0000-0001-9597-4374)
- Marco Orecchioni (ORCID: https://orcid.org/0000-0002-3602-8510)
- Karina Vázquez-Arreguín (ORCID: https://orcid.org/0000-0003-0846-0899)
- Kimberly Rivera-Caraballo (ORCID: https://orcid.org/0000-0001-9275-7286)
- Sara A. Murphy (ORCID: https://orcid.org/0000-0003-2722-0081)
- Kimya Jones (ORCID: https://orcid.org/0000-0001-8313-1695)
- Ravindra B Kolhe (ORCID: https://orcid.org/0000-0002-8283-2403)
- Balveen Kaur (ORCID: https://orcid.org/0000-0001-7738-0804)
- Upasana Sahu (ORCID: https://orcid.org/0000-0003-2473-9312)
- Rafał Pacholczyk (ORCID: https://orcid.org/0000-0002-9629-4829)
- Shilpa Sharma (ORCID: https://orcid.org/0009-0006-5019-4722)
- Bangxing Hong (ORCID: https://orcid.org/0000-0001-7458-0480)
- Amritanshu Sinha (ORCID: https://orcid.org/0000-0003-1006-0683)
- Kailash Vemuri (ORCID: https://orcid.org/0009-0001-3708-6296)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Augusta University (US)
- Augusta University Health (US)
- University of Maine at Augusta (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1402
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00