Clinical and Cytokine Features of Immune Effector Cell–Associated Hemophagocytic Lymphohistiocytosis–Like Syndrome
IEC-HS is a serious inflammatory toxicity of CAR T cells. We demonstrate that IEC-HS after CD22-directed CAR T-cell therapy is associated with lower rates of relapse yet higher NRM. CAR T-cell expansion and a 41-cytokine signature are associated with IEC-HS, and a simplified signature of IFNγ, IL10, and IL1RA precedes severe disease. See related commentary by Rocco and Shah, p. 163.
Authors
- Lori S. Muffly (ORCID: https://orcid.org/0000-0002-9887-6136)
- Kara L. Davis (ORCID: https://orcid.org/0000-0002-7182-2592)
- Neha Agarwal (ORCID: https://orcid.org/0000-0002-3792-6750)
- Sneha Ramakrishna (ORCID: https://orcid.org/0000-0001-7445-3190)
- Saurabh Dahiya (ORCID: https://orcid.org/0000-0001-8291-1796)
- Alexandria M. Jensen (ORCID: https://orcid.org/0000-0001-6337-9079)
- Matthew J. Frank (ORCID: https://orcid.org/0000-0002-2356-3354)
- Steven A. Feldman (ORCID: https://orcid.org/0000-0003-2098-3860)
- Juancarlos Cancilla (ORCID: https://orcid.org/0009-0002-2969-4571)
- Yi‐Jiun Su (ORCID: https://orcid.org/0000-0002-8372-1166)
- Agnes Reschke (ORCID: https://orcid.org/0000-0002-0861-1362)
- John H. Baird (ORCID: https://orcid.org/0000-0001-8291-6546)
- Liora M. Schultz (ORCID: https://orcid.org/0000-0001-9512-7597)
- Anne Marijn Kramer (ORCID: https://orcid.org/0000-0001-5239-7343)
- Bita Sahaf (ORCID: https://orcid.org/0000-0002-4157-3863)
- Shriya Syal (ORCID: https://orcid.org/0009-0008-6992-8815)
- David B. Miklos (ORCID: https://orcid.org/0000-0003-0717-4305)
- Hrishikesh K. Srinagesh (ORCID: https://orcid.org/0000-0001-9786-3010)
- Crystal L. Mackall (ORCID: https://orcid.org/0000-0003-0359-9023)
- Nikeshan Jeyakumar (ORCID: https://orcid.org/0000-0001-9979-4434)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- City Of Hope National Medical Center (US)
- Cancer Prevention Institute of California (US)
- Palo Alto University (US)
- Parker Institute for Cancer Immunotherapy (US)
- City of Hope (US)
- Linkou Chang Gung Memorial Hospital (TW)
- Stanford Blood Center (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1158/2643-3230.bcd-25-0262
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77