Meta-analysis of genome-wide association studies of doxorubicin-induced arrhythmia identifies <i>MMP16 and KCTD15 as risk loci</i>

Genetic variants at <i>KCTD15</i> and <i>MMP16</i> are associated with doxorubicin-related arrhythmia and cardiac events. <i>KCTD15</i> and <i>MMP16</i> are potential cardioprotective therapeutic targets.

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Journal
medRxiv
Published
2025-12-18
DOI
https://doi.org/10.64898/2025.12.16.25342433
Primary Topic
Chemotherapy-induced cardiotoxicity and mitigation
Type
article
Field-Weighted Citation Impact
0.00

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article

Meta-analysis of genome-wide association studies of doxorubicin-induced arrhythmia identifies MMP16 and KCTD15 as risk loci

Hugues Sicotte, Isaac Prah, Hector R. Villarraga, Pooja Prem Advani et al.
medRxiv
Chemotherapy-induced cardiotoxicity and mitigation
article

Meta-analysis of genome-wide association studies of doxorubicin-induced arrhythmia identifies MMP16 and KCTD15 as risk loci

Hugues Sicotte, Isaac Prah, Hector R. Villarraga, Pooja Prem Advani, Milagros Pereyra, Anthony C. Luehrs, Joseph S. Reddy, Konstantinos N. Lazaridis, Robert A. Vierkant, Nadine Norton, Thomas Matthew Habermann, Xiaolei Xu, Reza Arsanjani, Maryam Moossavi, James R. Cerhan, Nicholas Boddicker, Chadi Ayoub, Mohammed Tiseer Abbas, Melissa C. Larson, Jan B. Egan
article en

Abstract

Genetic variants at <i>KCTD15</i> and <i>MMP16</i> are associated with doxorubicin-related arrhythmia and cardiac events. <i>KCTD15</i> and <i>MMP16</i> are potential cardioprotective therapeutic targets.

medRxiv
Mayo Clinic (US), Jacksonville College (US), Mayo Clinic in Arizona (US), Mayo Clinic Hospital (US), Mayo Clinic in Florida (US)
U.S. Department of Defense, National Institutes of Health, Center for Individualized Medicine, Mayo Clinic, National Cancer Institute
Openalex Percentile: Top 42%
Chemotherapy-induced cardiotoxicity and mitigation
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