Meta-analysis of genome-wide association studies of doxorubicin-induced arrhythmia identifies <i>MMP16 and KCTD15 as risk loci</i>
Genetic variants at <i>KCTD15</i> and <i>MMP16</i> are associated with doxorubicin-related arrhythmia and cardiac events. <i>KCTD15</i> and <i>MMP16</i> are potential cardioprotective therapeutic targets.
Authors
- Hugues Sicotte (ORCID: https://orcid.org/0000-0002-0304-8515)
- Isaac Prah
- Hector R. Villarraga (ORCID: https://orcid.org/0000-0002-3675-6948)
- Pooja Prem Advani (ORCID: https://orcid.org/0009-0007-5470-3149)
- Milagros Pereyra (ORCID: https://orcid.org/0000-0003-4695-8436)
- Anthony C. Luehrs (ORCID: https://orcid.org/0009-0009-8446-5553)
- Joseph S. Reddy (ORCID: https://orcid.org/0000-0002-1783-4453)
- Konstantinos N. Lazaridis (ORCID: https://orcid.org/0000-0002-0437-681X)
- Robert A. Vierkant (ORCID: https://orcid.org/0000-0001-6242-5221)
- Nadine Norton (ORCID: https://orcid.org/0000-0002-3848-4288)
- Thomas Matthew Habermann (ORCID: https://orcid.org/0000-0003-3532-9132)
- Xiaolei Xu (ORCID: https://orcid.org/0000-0002-4928-3422)
- Reza Arsanjani (ORCID: https://orcid.org/0000-0001-7081-4286)
- Maryam Moossavi (ORCID: https://orcid.org/0000-0002-6891-535X)
- James R. Cerhan (ORCID: https://orcid.org/0000-0002-7482-178X)
- Nicholas Boddicker (ORCID: https://orcid.org/0000-0002-6784-2072)
- Chadi Ayoub (ORCID: https://orcid.org/0000-0001-5877-7478)
- Mohammed Tiseer Abbas
- Melissa C. Larson (ORCID: https://orcid.org/0000-0002-5430-8161)
- Jan B. Egan (ORCID: https://orcid.org/0000-0002-2155-3099)
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-18
- DOI
- https://doi.org/10.64898/2025.12.16.25342433
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- National Institutes of Health
- Center for Individualized Medicine, Mayo Clinic
- National Cancer Institute