Association of Brain Age With Physical Disability and Cognitive Impairment in People With Multiple Sclerosis of the Same Age
In a cohort unbiased by age differences, greater brain ageing was associated with worse performance on disability and cognitive tests, underscoring the potential of brain-PAD as a marker for neurodegeneration and disease severity in MS.
Authors
- James H. Cole (ORCID: https://orcid.org/0000-0003-1908-5588)
- Bas Jasperse (ORCID: https://orcid.org/0000-0003-1577-8299)
- Bernard M.J. Uitdehaag (ORCID: https://orcid.org/0000-0002-9226-7364)
- Eva M. M. Strijbis (ORCID: https://orcid.org/0000-0001-6705-5864)
- Bastiaan Moraal (ORCID: https://orcid.org/0000-0003-4559-1118)
- Len Bos (ORCID: https://orcid.org/0009-0006-7404-6716)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Hugo Vrenken (ORCID: https://orcid.org/0000-0001-9106-1172)
- Alle Meije Wink (ORCID: https://orcid.org/0000-0002-8197-0118)
- Menno Michiel Schoonheim (ORCID: https://orcid.org/0000-0002-2504-6959)
- Joep Killestein (ORCID: https://orcid.org/0000-0002-6347-5957)
Institutions
- Amsterdam Neuroscience (NL)
- Informa Healthcare (GB)
- University College London (GB)
Publication Details
- Journal
- Neurology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1212/wnl.0000000000214527
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amsterdam University Medical Centers
- Stichting MS Research